diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index ea9e23e5a..77ec85f4e 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -198,21 +198,25 @@ jobs:
           - testenv: py314-pyqt69
             os: ubuntu-24.04
             python: "3.14"
+          ### PyQt 6.10 (Python 3.14)
+          - testenv: py314-pyqt610
+            os: ubuntu-24.04
+            python: "3.14"
           ### macOS Ventura
-          - testenv: py314-pyqt69
+          - testenv: py314-pyqt610
             os: macos-13
             python: "3.14"
             args: "tests/unit"  # Only run unit tests on macOS
           ### macOS Sonoma (M1 runner)
-          - testenv: py314-pyqt69
+          - testenv: py314-pyqt610
             os: macos-14
             python: "3.14"
             args: "tests/unit"  # Only run unit tests on macOS
           ### Windows
-          - testenv: py314-pyqt69
+          - testenv: py314-pyqt610
             os: windows-2022
             python: "3.14"
-          - testenv: py314-pyqt69
+          - testenv: py314-pyqt610
             os: windows-2025
             python: "3.14"
     runs-on: "${{ matrix.os }}"
diff --git a/misc/requirements/requirements-pyqt-6.txt b/misc/requirements/requirements-pyqt-6.txt
index cdd38c426..cf32f5046 100644
--- a/misc/requirements/requirements-pyqt-6.txt
+++ b/misc/requirements/requirements-pyqt-6.txt
@@ -1,7 +1,8 @@
 # This file is automatically generated by scripts/dev/recompile_requirements.py
 
-PyQt6==6.9.1
-PyQt6-Qt6==6.9.2
-PyQt6-WebEngine==6.9.0
-PyQt6-WebEngine-Qt6==6.9.2
+PyQt6==6.10.0
+PyQt6-Qt6==6.10.0
+PyQt6-WebEngine==6.10.0
+PyQt6-WebEngine-Qt6==6.10.0
 PyQt6_sip==13.10.2
+--extra-index-url https://www.riverbankcomputing.com/pypi/simple/
diff --git a/misc/requirements/requirements-pyqt-6.txt-raw b/misc/requirements/requirements-pyqt-6.txt-raw
index 68a5db685..6b48354d2 100644
--- a/misc/requirements/requirements-pyqt-6.txt-raw
+++ b/misc/requirements/requirements-pyqt-6.txt-raw
@@ -2,3 +2,7 @@ PyQt6
 PyQt6-Qt6
 PyQt6-WebEngine
 PyQt6-WebEngine-Qt6
+
+# WORKAROUND for https://www.riverbankcomputing.com/pipermail/pyqt/2025-October/046347.html
+#@ add: --extra-index-url https://www.riverbankcomputing.com/pypi/simple/
+--extra-index-url https://www.riverbankcomputing.com/pypi/simple/
diff --git a/misc/requirements/requirements-pyqt.txt b/misc/requirements/requirements-pyqt.txt
index cdd38c426..cf32f5046 100644
--- a/misc/requirements/requirements-pyqt.txt
+++ b/misc/requirements/requirements-pyqt.txt
@@ -1,7 +1,8 @@
 # This file is automatically generated by scripts/dev/recompile_requirements.py
 
-PyQt6==6.9.1
-PyQt6-Qt6==6.9.2
-PyQt6-WebEngine==6.9.0
-PyQt6-WebEngine-Qt6==6.9.2
+PyQt6==6.10.0
+PyQt6-Qt6==6.10.0
+PyQt6-WebEngine==6.10.0
+PyQt6-WebEngine-Qt6==6.10.0
 PyQt6_sip==13.10.2
+--extra-index-url https://www.riverbankcomputing.com/pypi/simple/
diff --git a/misc/requirements/requirements-pyqt.txt-raw b/misc/requirements/requirements-pyqt.txt-raw
index 68a5db685..6b48354d2 100644
--- a/misc/requirements/requirements-pyqt.txt-raw
+++ b/misc/requirements/requirements-pyqt.txt-raw
@@ -2,3 +2,7 @@ PyQt6
 PyQt6-Qt6
 PyQt6-WebEngine
 PyQt6-WebEngine-Qt6
+
+# WORKAROUND for https://www.riverbankcomputing.com/pipermail/pyqt/2025-October/046347.html
+#@ add: --extra-index-url https://www.riverbankcomputing.com/pypi/simple/
+--extra-index-url https://www.riverbankcomputing.com/pypi/simple/
diff --git a/tox.ini b/tox.ini
index a1b505958..af558bb6d 100644
--- a/tox.ini
+++ b/tox.ini
@@ -57,8 +57,9 @@ deps =
     pyqt67: -r{toxinidir}/misc/requirements/requirements-pyqt-6.7.txt
     pyqt68: -r{toxinidir}/misc/requirements/requirements-pyqt-6.8.txt
     pyqt69: -r{toxinidir}/misc/requirements/requirements-pyqt-6.9.txt
+    pyqt610: -r{toxinidir}/misc/requirements/requirements-pyqt-6.10.txt
 commands =
-    !pyqt-!pyqt515-!pyqt5152-!pyqt62-!pyqt63-!pyqt64-!pyqt65-!pyqt66-!pyqt67-!pyqt68-!pyqt69: {envpython} scripts/link_pyqt.py --tox {envdir}
+    !pyqt-!pyqt515-!pyqt5152-!pyqt62-!pyqt63-!pyqt64-!pyqt65-!pyqt66-!pyqt67-!pyqt68-!pyqt69-!pyqt610: {envpython} scripts/link_pyqt.py --tox {envdir}
     {envpython} -bb -m pytest {posargs:tests}
     cov: {envpython} scripts/dev/check_coverage.py {posargs}