diff --git a/tox.ini b/tox.ini
index 2955c7b8a..a06d22050 100644
--- a/tox.ini
+++ b/tox.ini
@@ -7,7 +7,7 @@
 envlist = py38-pyqt515-cov,mypy,misc,vulture,flake8,pylint,pyroma,check-manifest,eslint,yamllint,actionlint
 distshare = {toxworkdir}
 skipsdist = true
-minversion = 3.15
+minversion = 3.20
 
 [testenv]
 setenv =
@@ -223,14 +223,18 @@ deps =
 commands =
     {envpython} -m sphinx -jauto -W --color {posargs} {toxinidir}/doc/extapi/ {toxinidir}/doc/extapi/_build/
 
-[testenv:build-release]
+[testenv:build-release{,-qt6}]
 basepython = {env:PYTHON:python3}
 passenv = *
+# Override default PyQt5 from [testenv]
+setenv =
+    qt6: QUTE_QT_WRAPPER=PyQt6
 usedevelop = true
 deps =
     -r{toxinidir}/requirements.txt
     -r{toxinidir}/misc/requirements/requirements-tox.txt
-    -r{toxinidir}/misc/requirements/requirements-pyqt.txt
+    !qt6: -r{toxinidir}/misc/requirements/requirements-pyqt.txt
+    qt6: -r{toxinidir}/misc/requirements/requirements-pyqt-6.txt
     -r{toxinidir}/misc/requirements/requirements-dev.txt
     -r{toxinidir}/misc/requirements/requirements-pyinstaller.txt
 commands =