>>> dif = lambda s: [x-s[i] for i,x in enumerate(s[1:])] >>> # or, dif = lambda s: [x-y for x,y in zip(s[1:],s)] >>> difn = lambda s, n: difn(dif(s), n-1) if n else s >>> s = [90, 47, 58, 29, 22, 32, 55, 5, 55, 73] >>> difn(s, 0) [90, 47, 58, 29, 22, 32, 55, 5, 55, 73] >>> difn(s, 1) [-43, 11, -29, -7, 10, 23, -50, 50, 18] >>> difn(s, 2) [54, -40, 22, 17, 13, -73, 100, -32] >>> from pprint import pprint >>> pprint( [difn(s, i) for i in xrange(10)] ) [[90, 47, 58, 29, 22, 32, 55, 5, 55, 73], [-43, 11, -29, -7, 10, 23, -50, 50, 18], [54, -40, 22, 17, 13, -73, 100, -32], [-94, 62, -5, -4, -86, 173, -132], [156, -67, 1, -82, 259, -305], [-223, 68, -83, 341, -564], [291, -151, 424, -905], [-442, 575, -1329], [1017, -1904], [-2921]]