Needs["DatabaseLink`"];
conn=OpenSQLConnection[JDBC["ODBC(DSN)","testdb"],"Username"->"John","Password"->"JohnsPassword"];
SQLExecute[conn,"UPDATE players SET name = `1`, score = `2`, active = `3` WHERE jerseyNum = `4`", {SQLArgument["Smith, Steve",42,True,99]}]
CloseSQLConnection[conn];