\ assuming the var 'db' contains an opened database with a schema matching the problem:
db @
"UPDATE players SET name=?1,score=?2,active=?3 WHERE jerseyNum=?4"
db:prepare var, stmt

\ bind values to the statement:
stmt @ 1 "Smith, Steve" db:bind
       2 42 db:bind
       3 true db:bind
       4 99 db:bind

\ execute the query
db @  swap db:exec